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KMID : 0895820140240020015
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Journal of Oriental Rehabilitation Medicine
2014 Volume.24 No. 2 p.15 ~ p.29
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Effects of Bangkeehwangkee-tang (fangj?huangqi-t?ng) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats
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Kim Dae-Hun
Kang Sung-In
Song Min-Yeong
Choi Jin-Bong
Bae Gil-Jun
Han Jeong-Seok
Yang Mi-Sung
Shin Yong-Jeen
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Abstract
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Objectives : We have studied to know effects of Bangkeehwangkee-tang on the mono-sodium iodoacetate (MIA) induced osteoarthritis in rats.
Methods : Osteoarthritis was induced by injection of monosodium iodoacetate into knee joint cavity of rats. Rats are devided into 4 groups; Sham, control, Bangkeehwangkee-tang, Shinbaro. Sham group was injected by normal saline into knee joint cavity only. Control group was taken no treatment and Experimental groups were taken extracts of Bangkee-hwangkee-tang and Shinbaro by orally once a day for 4 weeks. The content of TNF-α, IL- 1β and IL-6 in synovial fluids were analysed. COX-2 in chondrocytes and blood PGE2 concentration were analysed. Histopathological examination was performed by Safranin-O fast green staining and Mankins score checking.
Results : The content of TNF-α, IL-1β in experimental groups were decreased com-pared with control group. COX-2 in chondrocytes and blood PGE2 concentration in ex-perimental groups were decreased compared with control group. Histopathologically, os-teoarthritic scores of experimental groups were decreased compared with control group. But the content of IL-6 in synovial fluids was not significantly compared with control group.
Conclusions : According to these results, it can be suggested that Bangkeehwangkee- tang has anti-arthritic effects on the MIA induced osteoarthritis in rats. (
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KEYWORD
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Bangkeehwangkee-tang, Osteoarthritis, Monosodium iodoacetate
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